Higher pregnancy rates achieved with the use of intramuscular progesterone plus vaginal progesterone (crinone®8%) versus vaginal progesterone alone in oocyte recipient cycles

Objective: The objective of this study was to determine if the use of intramuscular (IM) progesterone (P) plus vaginal P (Crinone ® 8%, once daily) versus vaginal P alone improves outcome in oocyte recipient cycles. Design: Retrospective data analysis. Setting: Academically affiliated private fertility center. Patients: A total of 106 women undergoing donor recipient cycles utilizing two different luteal phase support protocols based on physician preference. Intervention (s): Group I received IM P plus vaginal P and Group II received vaginal P alone starting on the day of the donor's egg retrieval. Main Outcome Measures: Pregnancy rate (PR), clinical pregnancy rate (CPR), implantation rate (IR); live birth rate (LBR). Results: The PR, CPR, and LBR in were significantly higher in Group I (n = 79) than in Group II (n = 27). Conclusions: In oocyte recipient cycles, the use of IM P plus vaginal P significantly increased the PR, CPR, IR and LBR versus vaginal P alone.