Why the study?
Lifestyle factors are critical in osteoporosis management and linked to comorbid depression, but their patterns and the mediating role of the Dietary Inflammatory Index needed examination.
Do unhealthy and sedentary lifestyle patterns increase the risk of depression in adults with osteopenia or osteoporosis, and is this mediated by the Dietary Inflammatory Index?
Do unhealthy and sedentary lifestyle patterns increase the risk of depression in adults with osteopenia or osteoporosis, and is this mediated by the Dietary Inflammatory Index?
In women with osteopenia or osteoporosis, unhealthy and sedentary lifestyle patterns are associated with a higher risk of depression, a relationship that is partially mediated by a pro-inflammatory diet.
May inform depression risk assessment in women with osteopenia/osteoporosis; hypothesis-generating and requires prospective confirmation.
Objective: Lifestyle factors play a critical role in osteoporosis management and are closely linked to the development and progression of comorbid depression. This study examines lifestyle patterns and their association with depression in individuals with osteopenia or osteoporosis, while assessing the mediating role of the Dietary Inflammatory Index (DII). Methods: Data from the National Health and Nutrition Examination Survey (NHANES) 2009-2020 were analyzed using latent class analysis (LCA) to classify 3,384 adults based on their lifestyle behaviors. A generalized linear model (GLM) evaluated the effects of lifestyle patterns on depression, and mediation analysis tested associations between these patterns, DII, and Patient Health Questionnaire-9 (PHQ-9) scores. Results: = 0.009) groups were associated with higher depression risk in women. DII partially mediated the relationships between unhealthy lifestyle and PHQ-9 (effect coefficient = 0.095, 95% CI: 0.056-0.135) and between sedentary lifestyle and PHQ-9 (effect coefficient = 0.059, 95% CI: 0.017-0.115). Conclusion: These findings suggest that lifestyle patterns significantly influence depression in women with osteopenia or osteoporosis, with DII serving as a partial mediator.
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Wang et al. (2025) studied this question.
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