Population
Myosin subfragment 1 (S1) in complex with ADP and beryllium fluoride (S1.ADP.BeF3-)
Comparison
Differential scanning calorimetry vs S1 in complex with ADP and orthovanadate…
Design
Preclinical
Authors
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S1.ADP.BeF3- mimics the myosin transition state; leaves open isoform-specific dynamics in human cardiac muscle.
The S1.ADP.BeF3- complex can be considered a stable structural analogue of the myosin head.ADP.Pi transition state of myosin-catalyzed ATP hydrolysis.
Bobkov et al. (1993) studied this question.
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