Why the study?
Does transcranial Doppler sonography differentiate between multiinfarct dementia, Alzheimer's disease, and healthy controls based on pulsatility indices?
Does transcranial Doppler sonography differentiate between multiinfarct dementia, Alzheimer's disease, and healthy controls based on pulsatility indices?
Transcranial Doppler sonography demonstrates significantly increased pulsatility indices in patients with multiinfarct dementia, offering a potential diagnostic tool to differentiate it from Alzheimer's disease.
May support TCD differentiation of multiinfarct dementia; hypothesis-generating and requires prospective validation before practice change.
Primary degenerative dementia of the Alzheimer type (DAT) and multiinfarct dementia (MID) exhibit differences in cerebrovascular blood flow velocity profiles, which were investigated by means of transcranial Doppler sonography. The pulsatility indices, as angle-independent parameters of peripheral vascular resistance, measured in middle cerebral and basilar arteries of patients with MID, were significantly increased (P < 0.005) with respect to cases of primary DAT and to healthy age-matched controls. Approximately 75% of all MID patients exhibited small-vessel disease rather than thromboembolism from the extracranial arteries and the heart, as judged by extracranial and transcranial Doppler sonographies, computerized cerebral tomographies, EEGs, and, if necessary, 2-D echocardiographies.
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Biedert et al. (1995) studied this question.
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