April 13, 2012Echocardiography

Systolic Myocardial Mechanics in Patients with Anderson–Fabry Disease with and without Left Ventricular Hypertrophy and in Comparison to Nonobstructive Hypertrophic Cardiomyopathy

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Why the study?

Do myocardial mechanics assessed by Vector Velocity Imaging differ between Anderson-Fabry disease patients with and without LVH, nonobstructive HCM, and healthy controls?

Population

99 subjects including a genetically confirmed Anderson-Fabry disease cohort divided into those with left…

Comparison

Assessment of myocardial mechanics using Vector… vs Healthy controls and NHCM patients

Design

Cohort

Authors

CGChristiane GrunerCardiac Imaging FVFlavia VerocaiUniversidade Federal do Rio de Janeiro SCShemy CarassoHadassah Medical Center

Discussion

Member takes

Implication

May aid differentiation of AFD-LVH from NHCM; leaves open prognostic implications in prospective cohorts.

Structured PICO

Do myocardial mechanics assessed by Vector Velocity Imaging differ between Anderson-Fabry disease patients with and without LVH, nonobstructive HCM, and healthy controls?

Population

99 subjects including a genetically confirmed Anderson-Fabry disease (AFD) cohort divided into those with left ventricular hypertrophy (LVH+, n=19) and without LVH (LVH-, n=21), nonobstructive hypertrophic cardiomyopathy (NHCM) patients (n=19), and healthy controls (n=40).

Intervention

Assessment of myocardial mechanics using Vector Velocity Imaging applied to two-dimensional echocardiography

Comparator

Healthy controls and NHCM patients

Outcome

Longitudinal strain (LS), circumferential strain (CS), and base-to-apex CS gradientssurrogate

Anderson-Fabry disease patients show abnormal systolic myocardial mechanics even without LVH, and differences in circumferential strain can help differentiate AFD with LVH from nonobstructive HCM.

Limitations

small cohort

Cite This Study

Gruner et al. (2012) studied this question.

synapsesocial.com/papers/6a71ef8be36a167817e3922c https://doi.org/10.1111/j.1540-8175.2012.01704.x

Topics

Hypertrophic cardiomyopathy

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Bookmark

Systolic Myocardial Mechanics in Patients with Anderson–Fabry Disease with and without Left Ventricular Hypertrophy and in Comparison to Nonobstructive Hypertrophic Cardiomyopathy

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Topics

Systolic Myocardial Mechanics in Patients with Anderson–Fabry Disease with and without Left Ventricular Hypertrophy and in Comparison to Nonobstructive Hypertrophic Cardiomyopathy

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Topics

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