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July 14, 2018European Heart Journal - Cardiovascular Imaging

Prominent longitudinal strain reduction of left ventricular basal segments in treatment-naïve Anderson-Fabry disease patients

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Why the study?

Does regional longitudinal strain differ between treatment-naïve Anderson-Fabry disease patients and healthy controls?

Population

23 consecutive treatment-naïve Anderson-Fabry disease patients at diagnosis and 23 healthy controls without…

Comparison

Echocardiography with regional and global… vs Healthy controls matched for age and sex

Design

Case-control

Authors

RERoberta EspositoFederico II University HospitalMGMaurizio GalderisiCardio-OncologyCSCiro SantoroCardiac Imaging

Discussion

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Overview

Basal LS reduction may mark early AFD involvement; leaves open its diagnostic or prognostic value pending prospective studies.

Structured PICO

Does regional longitudinal strain differ between treatment-naïve Anderson-Fabry disease patients and healthy controls?

P
Population
23 consecutive treatment-naïve Anderson-Fabry disease (AFD) patients at diagnosis and 23 healthy controls without cardiovascular risk factors, matched for age and sex.
I
Intervention
Echocardiography with regional and global longitudinal strain (GLS) analysis
C
Comparator
Healthy controls matched for age and sex
O
Outcome
Regional left ventricular patterns of longitudinal strain (LS) and base-to-apex behaviour of LSsurrogate

Treatment-naïve Anderson-Fabry disease patients show an early reduction in left ventricular longitudinal strain primarily involving basal segments, even before ejection fraction is affected.

Cite This Study

Esposito et al. (2018) studied this question.

synapsesocial.com/papers/6a79719935e7b6bcc688fc07https://doi.org/10.1093/ehjci/jey108
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic implications of global LV dysfunction: a systematic review and meta-analysis of global longitudinal strain and ejection fraction2014 · 1,071 citations
  2. 2Prevalence of Fabry Disease in Female Patients With Late-Onset Hypertrophic Cardiomyopathy2004 · 273 citations
  3. 3Prognostic implication of relative regional strain ratio in cardiac amyloidosis2016 · 140 citations
  4. 4Reproducibility of native myocardial T1 mapping in the assessment of Fabry disease and its role in early detection of cardiac involvement by cardiovascular magnetic resonance2014 · 201 citations
  5. 5Standardization of adult transthoracic echocardiography reporting in agreement with recent chamber quantification, diastolic function, and heart valve disease recommendations: an expert consensus document of the European Association of Cardiovascular Imaging2017 · 857 citations