Why the study?
Conventional echocardiography is not sensitive in detecting preclinical Fabry cardiomyopathy before the development of LVH.
Does myocardial deformation analysis (GLS) detect preclinical Fabry cardiomyopathy before the development of LVH in patients carrying the mutated gene?
Comparison
Fabry patients without LVH vs Fabry patients with LVH vs healthy individuals
Design
Prospective cohort study
Authors
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GLS reduction may mark early myocardial involvement in Fabry gene carriers; hypothesis-generating and should not yet change practice.
Does myocardial deformation analysis (GLS) detect preclinical Fabry cardiomyopathy before the development of LVH in patients carrying the mutated gene?
Reduced global longitudinal strain can serve as an early imaging marker for detecting preclinical Fabry cardiomyopathy before the onset of left ventricular hypertrophy.
Lu et al. (2021) studied this question.
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