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December 6, 2021Cardiac failure reviewOpen Access

CA125 has emerged as a prognostic indicator and a potential guide for tailoring decongestion therapy in patients with heart failure.

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Why the study?

There is a need for a cost-effective prognostic biomarker in HF beyond natriuretic peptides, particularly for congestion, and appropriate diuretic titration strategies remain unclear.

What is the role of carbohydrate antigen 125 (CA125) as a prognostic biomarker and guide for decongestion therapy in patients with heart failure?

Design

Review

Authors

MKMarko KumrićTKTina Tičinović KurirJBJoško Božić

Discussion

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Overview

Highlights need for affordable congestion biomarkers beyond NPs in HF; leaves open optimal diuretic strategies pending RCTs.

Structured PICO

What is the role of carbohydrate antigen 125 (CA125) as a prognostic biomarker and guide for decongestion therapy in patients with heart failure?

P
Population
Patients with heart failure
I
Intervention
Carbohydrate antigen 125 (CA125) as a prognostic biomarker and guide for decongestion therapy
O
Outcome
Prognosis and therapeutic management in heart failure

This review highlights the emerging role of CA125 as a cost-effective biomarker for prognosis and guiding diuretic therapy in heart failure.

Cite This Study

Kumrić et al. (2021) studied this question.

synapsesocial.com/papers/6a71ef92ac440176ef2a6d29https://doi.org/10.15420/cfr.2021.22
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Carbohydrate Antigen 125 (CA 125): A Novel Biomarker in Acute Heart Failure2024 · 16 citations
  2. 2Carbohydrate antigen 125 and clinical outcomes in heart failure: systematic review and meta-analysis2025 · 7 citations
  3. 3From Tumor Marker to Congestion Indicator: The Expanding Role of CA‐125 in Heart Failure and Beyond2026
  4. 4Carbohydrate Antigen 125: A Promising Tool for Risk Stratification in Heart Diseases2018 · 31 citations
  5. 5159 Diagnostic and prognostic significance of cancer antigen 125 in heart failure. A real-world analysis using a global federated database2024