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February 9, 2018Biomarkers in Medicine

CA125 identifies patients at high risk of rehospitalizations and death, and is associated with hemodynamic data such as ejection fraction and right atrial pressure.

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Why the study?

Does Carbohydrate antigen 125 (CA125) measurement improve risk stratification in patients with heart diseases?

Population

Patients with heart diseases including pericarditis, atrial fibrillation, heart failure, and coronary artery…

Design

Review

Authors

FFFelipe FalcãoFOFlávio Roberto Azevedo de OliveiraMSMaria Cleide F C da Silva

Discussion

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Overview

CA125 may aid congestion monitoring across cardiac conditions; leaves open its role in routine risk stratification.

Structured PICO

Does Carbohydrate antigen 125 (CA125) measurement improve risk stratification in patients with heart diseases?

P
Population
Patients with heart diseases including pericarditis, atrial fibrillation, heart failure, and coronary artery disease
I
Intervention
Carbohydrate antigen 125 (CA125) measurement
O
Outcome
Risk stratification for short- and long-term adverse outcomes (rehospitalizations and death)surrogate

CA125 is a promising biomarker for monitoring congestion and inflammation, and for risk stratification in various heart diseases.

Cite This Study

Falcão et al. (2018) studied this question.

synapsesocial.com/papers/6a71ef92ac440176ef2a6d31https://doi.org/10.2217/bmm-2017-0452
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Carbohydrate Antigen 125 (CA 125): A Novel Biomarker in Acute Heart Failure2024 · 16 citations
  2. 2Carbohydrate Antigen 125: A Biomarker at the Crossroads of Congestion and Inflammation in Heart Failure2021 · 20 citations
  3. 3Carbohydrate antigen 125 and clinical outcomes in heart failure: systematic review and meta-analysis2025 · 7 citations
  4. 4From Tumor Marker to Congestion Indicator: The Expanding Role of CA‐125 in Heart Failure and Beyond2026
  5. 5Serum CA125: a prognostic biomarker for mortality in chronic heart failure2025 · 11 citations