Why the study?
Does hydrochlorothiazide maintain clinical status and reduce blood pressure compared to previous chlorothiazide therapy?
Does hydrochlorothiazide maintain clinical status and reduce blood pressure compared to previous chlorothiazide therapy?
Hydrochlorothiazide is an effective diuretic and antihypertensive agent that requires only one-tenth the dose of chlorothiazide and is well-tolerated.
Answers are grounded in this paper and cite their sources.
May support lower-dose hydrochlorothiazide in hypertension; case-report data leave equivalence hypothesis-generating and unconfirmed.
In most patients treated earlier with chlorothiazide, maintenance of the previous status was obtained with a dose of hydrochlorothiazide one-tenth that of chlorothiazide. An important advantage appears to be absence of complaints of weakness during early weeks of treatment. Intravenous administration of hydrochlorothiazide is convenient and effective therapy. In oral therapy, daily administration is preferred because a more constant level of "compensation" is desirable. Hypertensive patients without clinical congestive failure showed improvement both symptomatically and by fall in blood pressure.
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George J. Schwartz (1959) studied this question.
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