What does this research mean for the field?

A 25 mg daily dose of hydrochlorothiazide is as effective in lowering blood pressure as a 50 mg dose, while the higher dose causes potassium and magnesium depletion that can be prevented by adding triamterene. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 12, 1986Acta Medica Scandinavica

Antihypertensive and Biochemical Effects of Different Doses of Hydrochlorothiazide Alone or in Combination with Triamterene

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Why the study?

Does hydrochlorothiazide alone or in combination with triamterene improve blood pressure and biochemical profiles in patients with essential hypertension?

Population

26 patients with essential hypertension

Comparison

Hydrochlorothiazide 25 mg alone, 50 mg alone, or… vs Cross-over comparison between the different…

Design

RCT, Randomized to receive active therapy in a cross-over manner

Follow-up

3 months per treatment period

Authors

AKAntti KohvakkaUniversity of Helsinki HSHannu SaloUniversity of Helsinki AGAriel GordinOrion Corporation (Finland)

Discussion

Member takes

Implication

Lower-dose hydrochlorothiazide or triamterene coadministration avoids hypokalemia while preserving efficacy; confirms safer thiazide dosing in hypertension.

Key Points

This research aims to evaluate the antihypertensive and metabolic effects of different doses of hydrochlorothiazide and its combination with triamterene in patients with hypertension.
26 patients with essential hypertension were randomized after a 5-week run-in period.
Patients received different doses of hydrochlorothiazide and triamterene in a crossover manner for 3 months each.
Blood pressure and biochemical parameters, including serum potassium and magnesium, were measured throughout the study.
Both hydrochlorothiazide doses significantly lowered systolic and diastolic blood pressure (p<0.01).
50 mg hydrochlorothiazide led to significant serum potassium reduction compared to the run-in (p<0.01).
No significant changes were observed in serum magnesium or cholesterol levels during the study periods.

Structured PICO

Does hydrochlorothiazide alone or in combination with triamterene improve blood pressure and biochemical profiles in patients with essential hypertension?

Population

26 patients with essential hypertension

Intervention

Hydrochlorothiazide 25 mg alone, 50 mg alone, or 50 mg combined with triamterene (37.5 or 75 mg) once daily for 3 months per period

Comparator

Cross-over comparison between the different active therapies and baseline (run-in period)

Outcome

Systolic and diastolic blood pressuresurrogate

Hydrochlorothiazide 25 mg is as effective as 50 mg for lowering blood pressure, but higher doses cause metabolic adverse effects like hypokalemia which can be mitigated by adding triamterene.

Cite This Study

Kohvakka et al. (1986) studied this question.

synapsesocial.com/papers/6a129c75ea48cb855a352d08 https://doi.org/10.1111/j.0954-6820.1986.tb03327.x

Topics

Hypertension management

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Implication

Lower-dose hydrochlorothiazide or triamterene coadministration avoids hypokalemia while preserving efficacy; confirms safer thiazide dosing in hypertension.

Antihypertensive and Biochemical Effects of Different Doses of Hydrochlorothiazide Alone or in Combination with Triamterene

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Antihypertensive and Biochemical Effects of Different Doses of Hydrochlorothiazide Alone or in Combination with Triamterene

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

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