Key result
Low dose hydrochlorothiazide monotherapy reduced mean daytime ambulatory blood pressure from 159/105 to 145/97 mm Hg (P<0.005), with only 32% of patients achieving blood pressure control.
Why the study?
Does low dose hydrochlorothiazide monotherapy improve blood pressure control in South African black patients with mild to moderate hypertension?
Population
19 South African black patients with mild to moderate hypertension
Comparison
Hydrochlorothiazide 12.5 to 25 mg daily as… vs Baseline (after a 3-week placebo run-in period)
Design
Cohort
Follow-up
8 weeks
Authors
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May warrant caution with low-dose hydrochlorothiazide monotherapy; leaves open optimal regimens for South African black patients.
Does low dose hydrochlorothiazide monotherapy improve blood pressure control in South African black patients with mild to moderate hypertension?
p-value: p=<0.005
Low-dose hydrochlorothiazide monotherapy provides only moderate blood pressure control in South African black patients with mild to moderate hypertension, and the 25 mg dose is associated with significant decreases in serum potassium.
Skoularigis et al. (1995) studied mild to moderate hypertension (n=19). hydrochlorothiazide (HCTZ) vs. baseline was evaluated on mean daytime ambulatory blood pressure (p=<0.005). Low dose hydrochlorothiazide monotherapy reduced mean daytime ambulatory blood pressure from 159/105 to 145/97 mm Hg (P<0.005), with only 32% of patients achieving blood pressure control.
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