Population
Isolated right atrium of the rabbit
Comparison
Electrical stimulation to elicit premature beats vs Normal spontaneous rhythm
Design
Preclinical
Authors
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May explain post-pause sinus node shifts in animal models; leaves open relevance to human arrhythmia mechanisms.
In isolated rabbit right atria, premature beats that discharge the S-A node prematurely cause a prolonged postextrasystolic pause and a persistent pacemaker shift to a slower ectopic focus.
Bonke et al. (1969) studied this question.
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