Why the study?
Does local adenosine receptor blockade with aminophylline alter sympathetic and blood pressure responses to fatiguing exercise in healthy young volunteers?
Does local adenosine receptor blockade with aminophylline alter sympathetic and blood pressure responses to fatiguing exercise in healthy young volunteers?
Local adenosine receptor antagonism in exercising muscles accentuates sympathetic activation and blood pressure responses during fatiguing exercise.
Accentuates sympathetic and BP responses to exercise in healthy volunteers; leaves open adenosine's role in clinical exercise settings.
The role adenosine plays in evoking the exercise pressor reflex in humans remains controversial. We hypothesized that localized forearm adenosine receptor blockade would attenuate muscle sympathetic nerve activity (MSNA) responses to fatiguing handgrip exercise in humans. Blood pressure (Finometer), heart rate, and MSNA from the peroneal nerve were assessed in 11 healthy young volunteers during fatiguing isometric handgrip, postexercise circulatory occlusion (PECO), and passive muscle stretch during PECO. The protocol was performed before and after adenosine receptor blockade by local infusion of 40 mg aminophylline in saline via forearm Bier block (regional intravenous anesthesia). In the second experiment, the same amount of saline was infused via the Bier block. After aminophylline, the MSNA and blood pressure responses to fatiguing handgrip, PECO, and passive stretch (all P < 0.05) were significantly greater than during the control condition. Saline Bier block had no similar effects on the MSNA and blood pressure responses. These data suggest that adenosine receptor antagonism in the exercising muscles may accentuate sympathetic activation during fatiguing exercise.
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Cui et al. (2010) studied this question.
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