Why the study?
Elevated angiotensin II causes podocyte injury in hypertension, but the study and application of podocytes to understand RAAS signaling and modulation remain important in regenerative medicine.
Losartan counteracts angiotensin II-induced gene expression changes in human urine-derived podocytes, demonstrating their utility as an in vitro model for studying RAAS signaling and nephrotoxicity.
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Hypothesis-generating for podocyte-targeted RAAS modulation in hypertension; leaves open clinical translation pending prospective trials.
Thimm et al. (2023) studied this question.
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