Key result
Short-term treatment with Angiotensin II in cultured human podocytes increased phosphorylation of actin-associated proteins, including LCP1, leading to increased filopodia and lamellipodia formation.
Angiotensin II triggers actin cytoskeleton-associated signal transduction and phosphorylation of LCP1 in human podocytes, leading to structural changes.
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Does not inform clinical practice; extends in vitro evidence on Ang II podocyte cytoskeletal signaling.
Schenk et al. (2017) studied this question. Angiotensin II was evaluated on Changes in the phosphoproteome of human podocytes. Short-term treatment with Angiotensin II in cultured human podocytes increased phosphorylation of actin-associated proteins, including LCP1, leading to increased filopodia and lamellipodia formation.
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