July 7, 2015Clinical HypertensionOpen Access

Angiotensin II induces endoplasmic reticulum stress in podocyte, which would be further augmented by PI3-kinase inhibition

View Full Paper

Ask AI

Bookmark

Population

Cultured mouse podocytes

Comparison

Angiotensin II with or without PI3-kinase… vs Untreated control

Design

Preclinical

Follow-up

24 h

Authors

THTae‐Sun HaChungbuk National University Hospital HPHye-Young ParkSeoul National University Hospital SSSu-Bin SeongChonnam National University

Discussion

Member takes

Implication

May identify podocyte protection target; leaves open clinical relevance in human kidney disease.

Structured PICO

Population

Cultured mouse podocytes

Intervention

Angiotensin II (increasing doses) with or without PI3-kinase inhibitor (LY294002) or losartan

Comparator

Untreated control

Outcome

Endoplasmic reticulum (ER) stress markers (Bip, phospho-PERK, phospho-eIF2α, and ATF4 proteins) evaluated by Western blotting at 24 hsurrogate

Angiotensin II induces ER stress in podocytes via the PERK-eIF2α-ATF4 axis, which is augmented by PI3-kinase inhibition, suggesting a potential therapeutic target for podocyte injury.

Cite This Study

Ha et al. (2015) studied this question.

synapsesocial.com/papers/6a892ee76abbd4965f28b63d https://doi.org/10.1186/s40885-015-0018-5

View Full Paper

Ask AI

Bookmark

Angiotensin II induces endoplasmic reticulum stress in podocyte, which would be further augmented by PI3-kinase inhibition

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin II induces endoplasmic reticulum stress in podocyte, which would be further augmented by PI3-kinase inhibition

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider