Why the study?
Does Angiotensin II infusion induce nephrin expression changes and podocyte apoptosis in Sprague-Dawley rats?
Population
Sprague-Dawley rats
Comparison
Angiotensin II infusion (400 ng x kg x min) via… vs Normal saline infusion
Design
Preclinical, Randomly assigned
Follow-up
28 days
Authors
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Highlights potential Ang II-nephrin-apoptosis link in hypertensive rat models; leaves open relevance to human CKD mechanisms.
Does Angiotensin II infusion induce nephrin expression changes and podocyte apoptosis in Sprague-Dawley rats?
Angiotensin II infusion in rats induces hypertension, proteinuria, and podocyte apoptosis, which correlates with decreased nephrin expression.
Jia et al. (2008) studied this question.
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