Glycemic Variability: Both Sides of the Story

Case for a relationship between postprandial hyperglycemic variability and complication risk In both type 1 and type 2 diabetes, large prospective clinical studies have shown a strong relationship between time-averaged mean levels of glycemia as measured by HbA1c and diabetes complications (1). However, as reviewed elsewhere, in recent years several pieces of evidence have raised the possibility that glycemic instability may also contribute to the development of diabetes complications (2). Also reviewed elsewhere, in individ-uals with impaired glucose tolerance the