Why the study?
Does anticoagulant therapy prevent the extension of coronary thromboses and the development of mural thrombi in patients with coronary thrombosis and myocardial infarction?
Population
Human beings with coronary thrombosis with myocardial infarction (also mentions experimental animal models)
Design
Other
Authors
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Insufficient for practice change in MI; leaves open whether anticoagulants prevent thrombus extension without controlled trials.
Does anticoagulant therapy prevent the extension of coronary thromboses and the development of mural thrombi in patients with coronary thrombosis and myocardial infarction?
Early historical reports suggested that anticoagulants like heparin and dicumarol may prevent thrombus extension in myocardial infarction, though initial clinical use was limited by perceived risks and small sample sizes.
Irving S. Wright (1948) studied this question.
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