NR3C2 gene polymorphism is associated with risk of gestational hypertension in Han Chinese women

Figures

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  Figure 1. Sanger sequencing results. (A–C) rs5522 locus TT, TC, and CC genotypes, respectively. (D–F) rs2070951 locus CC, CG, and GG genotypes, respectively. (G–I) rs5534 locus CC, CT, and TT genotypes, respectively. (J–L) rs2248038 locus TT, TC, and CC genotypes, respectively. (M–O) rs9992256 locus AA, AG, and GG genotypes, respectively.

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  Figure 2. Hierarchical interaction graphs and interaction dendrogram. (A) In the interaction dendrogram, the red line depicts the synergy interaction and the orange line depicts weaker synergy interaction. The interaction becomes more intense moving from left to right. (B) In the hierarchical interaction graphs, entropy is indicated as a percentage at the bottom of each polymorphism, and the percentage on each line is the percentage interaction of entropy between 2 polymorphisms. The red line depicts synergy redundancy interaction and the blue line depicts redundancy interaction.

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  Figure 3. Distribution of high risk and low risk of gestational hypertension in the best model. Dark gray and light gray boxes depict the high- and low-risk factor combinations, respectively. Left and right bars within each box represent case and control, respectively. The heights of the bars are proportional to the sum of the samples in each group. The patterns of high- and low-risk cells differ across each of the different multilocus dimensions, which is evidence of gene–gene interaction.

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  Figure 4. Comparisons of systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels between different groups. (A) SBP levels of the gestational hypertension group and the control group. (B) SBP levels among subjects with the single-nucleotide polymorphism (SNP) locus of the NR3C2 gene. (C) DBP levels of the GH group and the control group. (D) DBP levels among subjects with the SNP locus of the NR3C2 gene.