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January 1, 1998ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)Open Access

Effects of In Vitro and In Vivo Exposure to Doxorubicin (Adriamycin) on Caffeine-Induced Ca2+ Release from Sarcoplasmic Reticulum and Contractile Protein Function in ‘Chemically-Skinned’ Rabbit Ventricular Trabeculae

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Population

'Chemically-skinned' rabbit ventricular trabeculae

Design

Preclinical

Authors

STShunsuke TakahashiKanagawa Dental UniversityMDMartin A. DenvirThe Queen's Medical Research InstituteLHLisbet HarderAarhus University Hospital

Discussion

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Implication

Hypothesis-generating for anthracycline cardiotoxicity; human studies needed before any clinical translation.

Structured PICO

P
Population
'Chemically-skinned' rabbit ventricular trabeculae
I
Intervention
In vitro and in vivo exposure to doxorubicin
O
Outcome
Sarcoplasmic reticulum (SR) Ca2+-content and contractile protein functionsurrogate

Doxorubicin causes Ca2+ overload in the sarcoplasmic reticulum, providing a potential mechanism for anthracycline-induced cardiomyopathy.

Cite This Study

Takahashi et al. (1998) studied this question.

synapsesocial.com/papers/6a71f15a2163a0a01bc5dc75https://doi.org/10.1254/jjp.76.405
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Doxorubicin cardiomyopathy is associated with a decrease in calcium release channel of the sarcoplasmic reticulum in a chronic rabbit model.1993 · 117 citations
  2. 2Chronic doxorubicin induced cardiomyopathy in rabbits: mechanical, intracellular action potential, and   adrenergic characteristics of the failing myocardium1990 · 30 citations
  3. 3The major metabolite of doxorubicin is a potent inhibitor of membrane-associated ion pumps. A correlative study of cardiac muscle with isolated membrane fractions.1987 · 172 citations
  4. 4Acute arrhythmogenicity of doxorubicin administration1987 · 171 citations
  5. 5Ryanodine activation and inhibition of the Ca2+ release channel of sarcoplasmic reticulum.1986 · 717 citations