Population
Wistar rats with congestive heart failure induced by myocardial infarction
Comparison
Myocardial infarction to induce congestive heart… vs Sham-operated animals
Design
Preclinical
Follow-up
6 weeks
Authors
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MCT1 upregulation may support metabolic adaptation in experimental HF; hypothesis-generating for human studies before any therapeutic consideration.
In a rat model of congestive heart failure, functional MCT1 is significantly upregulated, increasing lactate uptake capacity to support altered cardiac metabolism.
Jóhannsson et al. (2001) studied this question.
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