What question did this study set out to answer?

To evaluate clinical signs, pathomorphological lesions, viral load, and shedding dynamics in pigs exposed to an African swine fever virus isolate from an agricultural outbreak.

March 22, 2020PathogensOpen Access

Analysis of the Clinical Course of Experimental Infection with Highly Pathogenic African Swine Fever Strain, Isolated from an Outbreak in Poland. Aspects Related to the Disease Suspicion at the Farm Level

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Why the study?

The study aimed to characterize clinical signs and lesions from an African swine fever virus strain isolated during a 2018 outbreak, and assess risks of virus load, shedding, and recognition difficulties at the farm level.

Population

Twenty-two pigs

Comparison

Intranasal infection with different doses of African swine fever virus (Pol18_28298_O111)

Design

Experimental infection study

Authors

MWMarek WalczakUniversity of Life Sciences in Lublin JŻJ. ŻmudzkiNational Veterinary Research Institute NMNatalia Mazur-PanasiukJagiellonian University

Discussion

Member takes

Implication

Low-dose ASFV exposure may hinder farm-level detection; leaves open optimized surveillance thresholds pending field confirmation.

Key Points

To evaluate clinical signs, pathomorphological lesions, viral load, and shedding dynamics in pigs exposed to an African swine fever virus isolate from an agricultural outbreak.
Inoculated twenty-two pigs (N=22) intranasally with various doses (down to 5 HAU) of African swine fever virus strain Pol18_28298_O111.
Tracked clinical progression, incubation duration, mortality, viral distribution in organs, and viral shedding in urine, feces, and saliva.
Infection occurred at doses as low as 5 HAU with a minimum incubation period of 5 days post-infection, yielding an 80% to 100% mortality rate.
The most common lesions were splenomegaly alongside hyperemia and enlargement of lymph nodes, occurring in 82% of animals.
Viremic pigs shed virus in urine, feces, and saliva despite exhibiting delayed or absent fevers, and one chronically infected survivor showed no detectable viral DNA in the spleen, liver, bone marrow, or brain.

Cite This Study

Walczak et al. (2020) studied this question.

synapsesocial.com/papers/6a71f62be36a167817e396c0 https://doi.org/10.3390/pathogens9030237

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Analysis of the Clinical Course of Experimental Infection with Highly Pathogenic African Swine Fever Strain, Isolated from an Outbreak in Poland. Aspects Related to the Disease Suspicion at the Farm Level

Discussion

Member takes

Implication

Key Points

Cite This Study

Analysis of the Clinical Course of Experimental Infection with Highly Pathogenic African Swine Fever Strain, Isolated from an Outbreak in Poland. Aspects Related to the Disease Suspicion at the Farm Level

Discussion

Member takes

Implication

Key Points

Cite This Study

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