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March 22, 2015Transboundary and Emerging Diseases165 citationsOpen Access

Experimental Infection of Domestic Pigs with African Swine Fever Virus Lithuania 2014 Genotype II Field Isolate

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Why the study?

What are the clinical, virological, and humoral responses, and horizontal transmission rates in domestic pigs infected with the Lithuanian LT14/1490 African swine fever virus?

Population

18 domestic pigs

Design

Preclinical

Key result

Experimental infection with the Lithuanian ASFV genotype II isolate induced an acute disease resulting in 94.5% mortality in domestic pigs.

Authors

CGCarmina GallardoASAlejandro SolerRNRaquel Nieto

Discussion

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Member takes

Overview

High mortality confirms acute virulence of 2014 Lithuanian ASFV; leaves open the transmission role of rare asymptomatic survivors.

Structured PICO

What are the clinical, virological, and humoral responses, and horizontal transmission rates in domestic pigs infected with the Lithuanian LT14/1490 African swine fever virus?

P
Population
18 domestic pigs (8 experimentally inoculated and 10 naive in-contact) evaluated for horizontal transmission and clinical response to African swine fever virus.
I
Intervention
Experimental infection with Lithuanian LT14/1490 African swine fever virus (genotype II)
O
Outcome
Horizontal transmission, clinical, virological and humoral response (including mortality, viral load, and specific antibodies)hard clinical

The Lithuanian LT14/1490 African swine fever virus is highly virulent in domestic pigs, causing acute disease and near-total mortality, though asymptomatic survival can occur.

Limitations

  • The role of asymptomatic surviving animals in virus transmission needs further investigation.
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Cite This Study

Gallardo et al. (2015) studied African swine fever (n=18). Experimental infection with Lithuanian LT14/1490 ASF virus was evaluated on Mortality. Experimental infection with the Lithuanian ASFV genotype II isolate induced an acute disease resulting in 94.5% mortality in domestic pigs.

synapsesocial.com/papers/6aa01dc90c49fed23e62a9f7https://doi.org/10.1111/tbed.12346
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