Key result
Experimental infection with as little as 0.1 HAD50/ml of ASFV Armenia 07 strain caused sub-acute lethal disease in pigs, and the virus was successfully transmitted to naive pigs via direct contact.
Why the study?
The study was conducted to analyze the effect of different dose injections of ASFV Armenia 07 strain on clinical manifestations, virus-shedding patterns, histopathology, and direct contact transmission dynamics in pigs.
Population
Pigs (including 8-week-old naive and inoculated pigs)
Comparison
Intramuscular injection at different doses (0.1, 101, 103, 106 HAD50/ml) vs direct contact exposure
Design
Experimental infection animal study
Authors
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Dose effects on ASFV transmission in pigs are described; leaves open validation for field control strategies.
Even a very low dose (0.1 HAD50/ml) of ASFV Armenia 07 strain is sufficient to cause lethal disease in pigs via intramuscular injection, and the virus transmits slowly via direct contact.
Yamada et al. (2020) studied African swine fever (n=16). African swine fever virus Armenia 07 strain was evaluated on Clinical manifestations, virus-shedding patterns, and histopathology. Experimental infection with as little as 0.1 HAD50/ml of ASFV Armenia 07 strain caused sub-acute lethal disease in pigs, and the virus was successfully transmitted to naive pigs via direct contact.
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