Key result
Intramuscular inoculation and contact transmission with the Georgia 2007/1 ASFV strain resulted in acute disease in all pigs, with infectious virus first isolated in blood at 3.6 days for inoculated pigs, and 10.4 and 13.1 days for direct and indirect contact pigs, respectively.
Population
40 specific pathogen-free female Large White pigs (Sus scrofa domesticus) aged 7 weeks
Design
Preclinical, randomly housed in four independent isolation rooms
Follow-up
up to 18 days post-exposure
Authors
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ASFV shedding data in transmission models are hypothesis-generating; leaves open targeted control strategies for this virulent strain.
Absolute Event Rate: 3.6% vs 10.4%
p-value: p=<0.05
The Georgia 2007/1 ASFV strain causes acute disease with high viremia in domestic pigs, with transmission likely occurring via contact with blood, but shows limited potential to cause persistent infection.
Guinat et al. (2014) studied African swine fever virus (ASFV) infection (n=40). Intramuscular inoculation with Georgia 2007/1 ASFV strain vs. Within-pen and between-pen contact transmission was evaluated on Time to onset of infectiousness in blood (virus titration) (p=<0.05). Intramuscular inoculation and contact transmission with the Georgia 2007/1 ASFV strain resulted in acute disease in all pigs, with infectious virus first isolated in blood at 3.6 days for inoculated pigs, and 10.4 and 13.1 days for direct and indirect contact pigs, respectively.
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