Population
Frozen crystals (100 degrees K) of the KcsA K(+) channel
Comparison
Equilibration with solutions containing barium… vs Native state (absence of barium)
Design
Preclinical
Authors
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Supports multi-ion model in K+ channels; leaves open translation to human cardiac electrophysiology.
X-ray crystallography identifies the specific barium blocking site in the KcsA potassium channel, supporting a multi-ion interaction model in the selectivity filter.
Jiang et al. (2000) studied this question.
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