What question did this study set out to answer?

This research aims to investigate how rest intervals and muscle stretching affect contraction strength in feline cardiac muscles.

January 1, 1985The Japanese Journal of PhysiologyOpen Access

Length dependent potentiation and inhibition of post-rest twitch tension development in adult cat and kitten papillary muscles.

View Full Paper

Ask AI

Bookmark

Why the study?

Does muscle stretching affect post-rest contraction in adult cat and kitten papillary muscles similarly to inotropic interventions?

Population

Papillary muscles isolated from adult cats (body weight 1.4-3.4 kg, n=11) and kittens (0.25-0.84 kg, n=13).

Comparison

Muscle stretching, high frequency stimulation… vs Control conditions.

Design

Preclinical, Both the sequence of runs and the sequence of rests were…

Authors

RHR HisanoUnited States Department of Veterans Affairs HSHiroyuki SugaShinshu University INI. NinomiyaHiroshima International University

Discussion

Member takes

Implication

Reversed stretch effects in kitten vs adult cat muscle caution against age-agnostic models; leaves open human translation.

Key Points

This research aims to investigate how rest intervals and muscle stretching affect contraction strength in feline cardiac muscles.
Examined post-rest contractions in papillary muscles from adult cats and kittens.
Assessed the impact of muscle stretching and compared results with high frequency stimulation and high calcium interventions.
Measured contraction tension after rest intervals to evaluate potentiation and inhibition effects.
Muscle stretching increased post-rest potentiation and decreased post-rest inhibition in adult cat muscles.
The effects of muscle stretching in adult cats mirrored those of high frequency stimulation and high calcium levels.
In contrast, similar effects were reversed in kitten papillary muscles, indicating developmental differences.

Structured PICO

Does muscle stretching affect post-rest contraction in adult cat and kitten papillary muscles similarly to inotropic interventions?

Population

Papillary muscles isolated from adult cats (body weight 1.4-3.4 kg, n=11) and kittens (0.25-0.84 kg, n=13).

Intervention

Muscle stretching (from 90% to 95% and 100% of Lmax), high frequency stimulation (from 12/min to 20/min and 30/min), and high calcium concentration (from 2.5 mM to 3.75 and 5.0 mM).

Comparator

Control conditions (muscle length 90% of Lmax, stimulation frequency 12/min, calcium concentration 2.5 mM).

Outcome

Peak developed tension (peak DT), peak rate of tension development (peak dT/dt), and time to peak tension (TPT) of post-rest contraction.surrogate

Muscle stretching acts as a positive inotropic intervention in adult cat papillary muscles but has reversed effects in kitten papillary muscles, suggesting an age-dependent inotropic effect of muscle length change.

Limitations

Did not measure sarcomere length, which may change during the rest period and affect tension development.

Cite This Study

Hisano et al. (1985) studied this question.

synapsesocial.com/papers/6a71f7f3b5c1fe5ca9dfec7a https://doi.org/10.2170/jjphysiol.35.147

View Full Paper

Ask AI

Bookmark

Length dependent potentiation and inhibition of post-rest twitch tension development in adult cat and kitten papillary muscles.

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Length dependent potentiation and inhibition of post-rest twitch tension development in adult cat and kitten papillary muscles.

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider