Key result
Theophylline and caffeine inhibit canine ventricular rest-twitch potentiation, while epinephrine, manganese, and D600 do not.
Population
Isolated canine right ventricular muscle and rabbit papillary muscle
Comparison
Rest periods and pharmacological agents vs Steady-state contraction / baseline
Design
Preclinical
Authors
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Distinguishes rest-twitch potentiation mechanisms from steady-state contraction in canine myocardium; leaves open relevance to human cardiac physiology.
Rest-twitch potentiation in canine ventricular muscle is inhibited by theophylline and caffeine, suggesting its mechanism differs from steady-state contraction regulation.
Endoh et al. (1981) studied this question. Theophylline, caffeine, epinephrine, manganese, and D 600 was evaluated on Rest-twitch potentiation (RTP) and steady-state contraction. Rest-twitch potentiation in canine ventricular muscle was inhibited by theophylline and caffeine, but unaffected by epinephrine, manganese, and D 600.
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