Population
Isolated papillary muscle of guinea pigs
Comparison
Extra-stimulation with varying coupling… vs Different coupling intervals and rest periods…
Design
Preclinical
Authors
Loading...
Coupling interval modulates PESP in this animal model; leaves open any clinical relevance or theophylline effects in humans.
The coupling ratio of extra-stimulation influences postextrasystolic potentiation, likely by varying the relative contributions of trans-sarcolemmal calcium influx and sarcoplasmic reticulum calcium release.
Asayama et al. (1989) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: