Population
Zebrafish embryos (wild-type, erbb2 mutants, tnnt2a morphants, and myh6 morphants)
Comparison
Genetic and morpholino manipulations combined… vs Wild-type zebrafish embryos
Design
Preclinical
Authors
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Zebrafish data implicate ErbB2, contractility, and flow in trabeculation steps; leaves open mammalian relevance and therapeutic translation.
High-resolution 4D imaging reveals that cardiac trabeculation in zebrafish involves a two-step process of luminal protrusion extension followed by abluminal constriction, which is differentially regulated by contractility, blood flow, and ErbB2 signaling.
Staudt et al. (2014) studied this question.
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