January 3, 2011Developmental Dynamics

Dependence of cardiac trabeculation on neuregulin signaling and blood flow in zebrafish

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Population

Zebrafish embryos

Design

Preclinical

Authors

CPCourtney PeshkovskyNewark Beth Israel Medical Center RTRonald TotongNew York University DYDeborah YelonUniversity of California, San Diego

Discussion

Member takes

Implication

Zebrafish findings are hypothesis-generating for trabeculation defects; leaves open translation to human congenital heart disease.

Structured PICO

Population

Zebrafish embryos

Intervention

Modulation of Neuregulin/ErbB signaling and blood flow

Outcome

Cardiac trabeculation (initiation, propagation, and network elaboration)surrogate

Neuregulin/ErbB signaling and optimal blood flow are critical for cardiac trabeculation in zebrafish embryos, providing a valuable model for investigating congenital heart defects.

Cite This Study

Peshkovsky et al. (2011) studied this question.

synapsesocial.com/papers/6a71f929febe604dd70a604d https://doi.org/10.1002/dvdy.22526

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Bookmark

Dependence of cardiac trabeculation on neuregulin signaling and blood flow in zebrafish

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Dependence of cardiac trabeculation on neuregulin signaling and blood flow in zebrafish

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider