Differences in the Neuronal Removal of Circulating Epinephrine and Norepinephrine
Population
Healthy subjects, patients with cardiovascular disorders, and rabbits
Comparison
Administration of desipramine to block neuronal… vs Norepinephrine extraction and clearance
Design
Other
Authors
Discussion
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Member takes
Implication
May require adjustment when interpreting plasma epinephrine/norepinephrine ratios for sympathetic tone; leaves open any impact on cardiovascular risk assessment.
Structured PICO
P
Population
Healthy subjects, patients with cardiovascular disorders, and rabbits
I
Intervention
Administration of desipramine to block neuronal uptake, and infusion of [3H]epinephrine and [3H]norepinephrine
C
Comparator
Norepinephrine extraction and clearance
O
Outcome
Cardiac extractions or plasma clearances of epinephrine compared to norepinephrinesurrogate
Epinephrine is removed significantly less avidly than norepinephrine by neuronal uptake, highlighting differences in their physiological clearance mechanisms.
Cite This Study
Eisenhofer et al. (1990) studied this question.