Why the study?
Is the aortocoronary sinus extraction of epinephrine reduced in patients with left ventricular failure compared to those without heart failure?
Population
22 patients, comprising 12 patients with documented left ventricular failure secondary to mechanical…
Comparison
Measurement of simultaneous plasma catecholamine… vs Patients with no history of heart failure
Design
Case-control
Authors
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Suggests specific cardiac catecholamine uptake depression in heart failure; hypothesis-generating for its role in progression or therapy.
Is the aortocoronary sinus extraction of epinephrine reduced in patients with left ventricular failure compared to those without heart failure?
The sympathetic neuronal membrane uptake system for catecholamines is specifically depressed in the failing heart, independent of peripheral sympathetic nervous system function.
Rose et al. (1983) studied this question.
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