Augmented Sympathetic Neurotransmitter Activity in the Peripheral Vascular Bed of Patients with Congestive Heart Failure and Cardiac Norepinephrine Depletion
Why the study?
Are sympathetic neurotransmitter stores and adrenergic receptor responses in the peripheral vascular bed altered in patients with congestive heart failure?
Population
17 patients, comprising 8 with congestive heart failure and 9 with heart disease but without heart failure.
Comparison
Intra-arterial injections of tyramine and… vs Patients with heart disease but without heart…
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Suggests heightened peripheral sympathetic activity in HF; leaves open causal role or therapeutic targeting.
Structured PICO
Are sympathetic neurotransmitter stores and adrenergic receptor responses in the peripheral vascular bed altered in patients with congestive heart failure?
P
Population
17 patients, comprising 8 with congestive heart failure and 9 with heart disease but without heart failure.
I
Intervention
Intra-arterial injections of tyramine and norepinephrine.
C
Comparator
Patients with heart disease but without heart failure.
O
Outcome
Vascular resistance and blood flow in the calf following intra-arterial injections.surrogate
Patients with congestive heart failure exhibit augmented sympathetic neurotransmitter activity in the peripheral vascular bed, suggesting elevated plasma norepinephrine levels derive partly from these peripheral stores.
Cite This Study
Kramer et al. (1968) studied this question.