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January 1, 2003Hypertension ResearchOpen Access

Plasma Adrenomedullin Is Closely Correlated with Pulse Wave Velocity in Middle-Aged and Elderly Patients

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Population

126 inpatients aged 30 to 75 years with or without varying degrees of atherosclerosis. Excluded: severe…

Design

Cross-sectional, Those who recorded the AM and endothelin-1 levels were…

Authors

TKToshihiro KitaUniversity of MiyazakiKKKazuo KitamuraNippon Dental UniversitySHSeiichi HashidaEhime University

Discussion

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Implication

Supports AM as potential arterial sclerosis marker; leaves open its prognostic utility in prospective cohorts.

Structured PICO

P
Population
126 inpatients aged 30 to 75 years with or without varying degrees of atherosclerosis. Excluded: severe heart failure (LVEF <40%), valvular disease, aortic aneurysm, renal failure (serum creatinine ≥1.2mg/dl), liver cirrhosis, neurological disease with paralysis, inflammatory disease, neoplasm, or a history of acute cardiovascular accident within the previous 3 months.
O
Outcome
Correlation between pulse wave velocity (PWV) and plasma adrenomedullin (AM) concentrationsurrogate

Plasma adrenomedullin concentration is positively correlated with pulse wave velocity and could serve as a biochemical marker of advanced arterial sclerosis.

Limitations

  • Medications could affect the PWV and AM level in risk-loading patients
  • Cross-sectional design means the therapeutic effect of anti-atherosclerotic drugs administered over a long period of time is unknown

Cite This Study

Kita et al. (2003) studied this question.

synapsesocial.com/papers/6a71fc2878a11c550e0be554https://doi.org/10.1291/hypres.26.887
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Also Consider

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