Why the study?
Does endogenous adrenomedullin protect against cardiovascular damage induced by Ang II and high salt in mice?
Population
Knockout mice with disruption of adrenomedullin (AM) peptide alone (AM+/- and AM+/+ mice)
Comparison
Angiotensin II administration on a high-salt… vs AM+/+ mice receiving the same Ang II/salt…
Design
Preclinical
Follow-up
12 days
Authors
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Preclinical data suggest endogenous adrenomedullin protects against Ang II/salt vascular injury in mice; leaves open human translation and therapeutic targeting.
Does endogenous adrenomedullin protect against cardiovascular damage induced by Ang II and high salt in mice?
Endogenous adrenomedullin protects against cardiovascular damage and oxidative stress induced by angiotensin II and high salt in a mouse model.
Shimosawa et al. (2002) studied this question.
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