Why the study?
Does adrenomedullin inhibit angiotensin II-induced oxidative stress and gene expression in rat aortic endothelial cells?
Population
Rat aortic endothelial cells prepared from the thoracic aorta of 6-week-old male Sprague-Dawley rats
Comparison
Adrenomedullin pretreatment for 1 hour vs Angiotensin II alone, or untreated control cells
Design
Preclinical
Authors
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Should not change clinical practice; leaves open adrenomedullin's vasculoprotective role in human hypertension.
Does adrenomedullin inhibit angiotensin II-induced oxidative stress and gene expression in rat aortic endothelial cells?
Adrenomedullin potently blocks Ang II-stimulated intracellular ROS generation and subsequent redox-sensitive gene expression in endothelial cells, suggesting a vasculoprotective role against pro-oxidant stimuli.
Yoshimoto et al. (2005) studied this question.
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