Key result
Heterozygous adrenomedullin knockout mice exhibited increased intimal thickening and oxidative stress after cuff injury compared to wild-type mice, suggesting a protective role of endogenous AM.
Why the study?
Does endogenous adrenomedullin protect against vascular response to injury in mice?
Population
Heterozygous adrenomedullin knockout (AM+/-) mice and wild-type (AM+/+) mice with cuff-injured femoral artery
Comparison
Adrenomedullin gene transfection, NADH oxidase… vs Untreated AM+/- mice and wild-type (AM+/+) mice
Design
Preclinical
Authors
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Hypothesis-generating for adrenomedullin in vascular protection; leaves open translation to human disease or therapy.
Does endogenous adrenomedullin protect against vascular response to injury in mice?
Endogenous adrenomedullin protects against vascular injury-induced intimal hyperplasia in mice by inhibiting oxidative stress.
Kawai et al. (2004) studied Vascular response to injury. Heterozygous adrenomedullin knockout (AM+/-) vs. Wild-type (AM+/+) mice was evaluated on Intimal thickening of the cuff-injured femoral artery and oxidative stress. Heterozygous adrenomedullin knockout mice exhibited increased intimal thickening and oxidative stress after cuff injury compared to wild-type mice, suggesting a protective role of endogenous AM.
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