Key result
Adrenomedullin overexpression cuts post-ischemic serum urea nitrogen ~61% in preclinical renal injury.
Why the study?
The role of endogenous adrenomedullin in the regulation of vascular tone and protection against ischemic renal injury was not fully understood.
Does endogenous adrenomedullin regulate vascular tone and protect against ischemic renal injury in mice?
Population
Adrenomedullin transgenic, heterozygote knockout, and wild-type mice
Comparison
Genetic overexpression or knockout of AM and pharmacological agents vs wild-type mice
Design
Preclinical experimental study
Follow-up
24 hours after ischemic injury
Authors
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Supports adrenomedullin as renoprotective in murine ischemia; leaves open translation to human AKI therapies.
Does endogenous adrenomedullin regulate vascular tone and protect against ischemic renal injury in mice?
p-value: p=<0.05
Endogenous adrenomedullin plays a physiological role in regulating vascular tone and protects renal tissues from ischemia/reperfusion injury via nitric oxide release.
Nishimatsu et al. (2002) studied Ischemic renal injury. Adrenomedullin overexpression (TG) vs knockout (KO) vs. Wild-type (WT) mice was evaluated on Serum urea nitrogen 24 hours after bilateral renal artery clamp (p=<0.05). Endogenous adrenomedullin overexpression protected against ischemic renal injury, with significantly lower serum urea nitrogen in transgenic mice compared to wild-type (38 vs 98 mg/dL, P<0.05).
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