January 1, 2000Hypertension

Increase in Renal Medullary Nitric Oxide Synthase Activity Protects From Norepinephrine-Induced Hypertension

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Population

Conscious Sprague-Dawley rats

Comparison

Intravenous infusion of a subpressor dose of… vs Intravenous norepinephrine alone or control rats

Design

Preclinical

Follow-up

7 days

Authors

MSM SzentiványiJahn Ferenc Dél-Pesti Kórház és Rendelőintézet AZAi-Ping ZouSemmelweis University CMCelso Y. MaedaSemmelweis University

Discussion

Member takes

Implication

Hypothesis-generating for renal medullary alpha2-NO buffering of adrenergic hypertension; leaves open human translation and requires prospective validation.

Structured PICO

Population

Conscious Sprague-Dawley rats

Intervention

Intravenous infusion of a subpressor dose of norepinephrine (8 microg. kg(-1). h(-1)) combined with renal medullary interstitial infusion of the alpha(2)-receptor antagonist rauwolscine (1 microg. kg(-1). min(-1)) or NOS inhibitor N(G)-nitro-L-arginine methyl ester (75 microg. kg(-1). h(-1))

Comparator

Intravenous norepinephrine alone or control rats

Outcome

Renal medullary nitric oxide synthase (NOS) activity and mean arterial pressuresurrogate

Renal medullary alpha2-receptor-mediated increases in nitric oxide synthase activity act as a counterregulatory mechanism to buffer the hypertensive effects of moderate elevations in renal adrenergic activity.

Cite This Study

Szentiványi et al. (2000) studied this question.

synapsesocial.com/papers/6a751e291646b2abe503531f https://doi.org/10.1161/01.hyp.35.1.418

Topics

Hypertension management

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Implication

Hypothesis-generating for renal medullary alpha2-NO buffering of adrenergic hypertension; leaves open human translation and requires prospective validation.

Increase in Renal Medullary Nitric Oxide Synthase Activity Protects From Norepinephrine-Induced Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Increase in Renal Medullary Nitric Oxide Synthase Activity Protects From Norepinephrine-Induced Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider