A core outcome set for future male infertility research: development of an international consensus

Michael P. Rimmer; Ruth Howie; Richard A. Anderson; Christopher L. R. Barratt; Kurt T. Barnhart; Yusuf Beebeejaun; Ricardo Pimenta Bertolla; Pietro Bortoletto; Robert E. Brannigan; Astrid EP Cantineau; Ettore Caroppo; Barbara Collura; Kevin Coward; W. Colin Duncan; Michael L. Eisenberg; Steven A. Gellatly; Christian De Geyter; Dimitrios G. Goulis; Ralf Henkel; Vu N A Ho; Alayman Hussein; Carin Huyser; Jozef H Kadijk; Mohan S. Kamath; Shadi Khashaba; Hajra Khattak; Yoshitomo Kobori; Julia Kopeika; Tansu Küçük; Saturnino Luján; Thabo Matsaseng; Raj Mathur; Kevin McEleny; Rod T. Mitchell; Ben W. Mol; Alfred Murage; Ernest Hung Yu Ng; Allan Pacey; Antti Perheentupa; Stefan S. du Plessis; Nathalie Rives; Ippokratis Sarris; Peter N. Schlegel; Majid Shabbir; Maciej Śmiechowski; Venkatesh Subramanian; Sesh Kamal Sunkara; Basil C. Tarlatzis; Frank Tüttelmann; Andy Vail; Madelon van Wely; Mónica H. Vazquez‐Levin; Lan N. Vuong; Alex Wang; Rui Wang; James MN Duffy; Cindy Farquhar; Craig Niederberger

doi:10.1093/humrep/deaf039

February 21, 2025Human ReproductionOpen Access

A core outcome set for future male infertility research: development of an international consensus

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Key Points

To develop an international consensus-based core outcome set for male infertility randomized controlled trials and systematic reviews.
Conducted a two-round Delphi survey including 334 participants from 39 countries.
Convened consensus development workshops involving 44 participants from 21 countries, including healthcare professionals, researchers, and individuals with lived experience of infertility.
Established core outcomes including standard WHO-recommended semen analysis, ultrasound-confirmed viable intrauterine pregnancy, and pregnancy loss (accounting for ectopic pregnancy, miscarriage, stillbirth, and termination).
Consensus finalized core perinatal and neonatal outcomes, encompassing live birth, gestational age at delivery, birthweight, neonatal mortality, and major congenital anomalies.

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Implication

Delphi consensus study establishes a standardized core outcome set for male infertility trials, highlighting improved clinical reporting and trial comparability.

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Rimmer et al. (2025) studied this question.

synapsesocial.com/papers/6a71fd3a5d37378ac1def23b https://doi.org/10.1093/humrep/deaf039

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A core outcome set for future male infertility research: development of an international consensus

Key Points

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Implication

Discussion

Cite This Study

A core outcome set for future male infertility research: development of an international consensus

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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