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November 1, 1976Clinical Endocrinology

A Radioimmunoassay for Growth Hormone Release‐inhibiting Hormone: Method and Quantitative Tissue Distribution

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Population

Rat tissues (2 m acetic acid extracts)

Design

Preclinical

Authors

СKС. KronheimUniversity of Cape TownMBMichael BerelowitzStony Brook UniversityBPB. L. PimstoneUniversity of Cape Town

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Implication

Rat GHRIH mapping is hypothesis-generating; leaves open human distribution, function, and therapeutic relevance.

Structured PICO

P
Population
Rat tissues (2 m acetic acid extracts)
I
Intervention
Radioimmunoassay using specific antiserum to haemocyanin conjugated synthetic growth hormone release inhibiting hormone (GHRIH)
O
Outcome
GHRIH content and tissue distributionsurrogate

The development of a sensitive radioimmunoassay for GHRIH revealed its widespread distribution in both the central nervous system and specific extra-neurological tissues in rats.

Cite This Study

Kronheim et al. (1976) studied this question.

synapsesocial.com/papers/6a71fd9987f9210571286aabhttps://doi.org/10.1111/j.1365-2265.1976.tb03865.x
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1THE PREPARATION OF 131I-LABELLED HUMAN GROWTH HORMONE OF HIGH SPECIFIC RADIOACTIVITY1963 · 10,183 citations
  2. 2PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT1951 · 318,692 citations