July 31, 2008AJP Regulatory Integrative and Comparative PhysiologyOpen Access

Cardiovascular responses to peripheral chemoreflex activation and comparison of different methods to evaluate baroreflex gain in conscious mice using telemetry

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Population

Conscious mice

Design

Preclinical

Authors

VBValdir A. BragaUniversidade Federal da Paraíba MBMelissa A. BurmeisterWilliam Carey University RSRam V. SharmaInstitute of Management Technology

Discussion

Member takes

Implication

Establishes conscious mouse chemoreflex model with validated baroreflex methods; leaves open translation to human hypoxia-related disease.

Structured PICO

Population

Conscious mice

Intervention

Peripheral chemoreceptor stimulation by potassium cyanide (KCN); comparison of pharmacological (phenylephrine and sodium nitroprusside) vs sequence method for baroreflex sensitivity

Outcome

Cardiovascular responses (blood pressure and heart rate) to peripheral chemoreflex activation; reliability of baroreflex sensitivity analysis methodssurrogate

This study characterizes the chemoreflex in conscious mice and validates methods for evaluating baroreflex sensitivity, establishing a model for studying hypoxia-related diseases like obstructive sleep apnea.

Cite This Study

Braga et al. (2008) studied this question.

synapsesocial.com/papers/6a71fe76f44fa9f079dfa033 https://doi.org/10.1152/ajpregu.90375.2008

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Implication

Establishes conscious mouse chemoreflex model with validated baroreflex methods; leaves open translation to human hypoxia-related disease.

Cardiovascular responses to peripheral chemoreflex activation and comparison of different methods to evaluate baroreflex gain in conscious mice using telemetry

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cardiovascular responses to peripheral chemoreflex activation and comparison of different methods to evaluate baroreflex gain in conscious mice using telemetry

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider