Population
Rabbit femoral artery constant perfusion model in vivo
Comparison
Beta-adrenoceptor stimulation with isoprenaline… vs Responses in the absence of L-NAME
Design
Preclinical
Authors
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NO may mediate beta2- and cAMP-driven vasodilation in vivo; extends mechanistic data in rabbits but leaves open human relevance.
Beta2-adrenergic stimulation and cyclic AMP elevation activate the L-arginine/NO system in rabbit femoral arteries in vivo, contributing significantly to vasodilatation.
Xu et al. (2000) studied this question.
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