Key result
Amlodipine, unlike verapamil or nifedipine, reduced perfusion pressure partly through a nitric oxide-dependent mechanism, with L-NAME attenuating its effect from 33.2% to 22.5% (P=0.002).
Why the study?
Does amlodipine induce vasorelaxation through a nitric oxide-dependent mechanism compared to verapamil or nifedipine in rabbit femoral artery?
Population
Anaesthetized rabbits undergoing femoral artery ligation
Comparison
Intra-arterial amlodipine 10 micromol x kg(-1) vs Intra-arterial verapamil or nifedipine 10…
Design
Preclinical
Authors
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Amlodipine's NO/kinin-dependent dilation in rabbit arteries may differ from other CCBs; leaves open human relevance and mechanism confirmation.
Does amlodipine induce vasorelaxation through a nitric oxide-dependent mechanism compared to verapamil or nifedipine in rabbit femoral artery?
p-value: p=0.002
Amlodipine, unlike verapamil or nifedipine, induces vasorelaxation in rabbit femoral arteries partly through a nitric oxide- and kinin-dependent mechanism, possibly via ACE inhibition.
Xu et al. (2002) studied this question. Amlodipine vs. Verapamil or nifedipine was evaluated on Reduction in perfusion pressure (p=0.002). Amlodipine, unlike verapamil or nifedipine, reduced perfusion pressure partly through a nitric oxide-dependent mechanism, with L-NAME attenuating its effect from 33.2% to 22.5% (P=0.002).
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