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April 21, 1997The Journal of Cell BiologyOpen Access

High Rates of Actin Filament Turnover in Budding Yeast and Roles for Actin in Establishment and Maintenance of Cell Polarity Revealed Using the Actin Inhibitor Latrunculin-A

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Population

Budding yeast strains, including mutants in components of the actin cytoskeleton and 19 different proteins…

Design

Preclinical

Follow-up

2-5 min (for actin disruption)

Authors

KAKathryn R. AyscoughUniversity of SheffieldJSJoel StrykerUniversity of California, Santa CruzNPNavin PokalaNew York Institute of Technology

Discussion

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Implication

Rapid actin turnover governs yeast polarity; leaves open relevance to mammalian cardiomyocyte cytoskeletal function.

Structured PICO

P
Population
Budding yeast strains, including mutants in components of the actin cytoskeleton and 19 different proteins implicated in cell polarity development
I
Intervention
Latrunculin-A (LAT-A)
O
Outcome
Actin cytoskeleton disruption and polarized localization of proteins

Actin filaments in yeast undergo rapid turnover and are essential for the establishment and maintenance of cell polarity through both actin-dependent and independent pathways.

Cite This Study

Ayscough et al. (1997) studied this question.

synapsesocial.com/papers/6a7204e553da1ffdb507cb7bhttps://doi.org/10.1083/jcb.137.2.399
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Yeast actin filaments display ATP-dependent sliding movement over surfaces coated with rabbit muscle myosin.1992 · 59 citations
  2. 2Tropomyosin is essential in yeast, yet the TPM1 and TPM2 products perform distinct functions.1995 · 146 citations
  3. 3Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin.1994 · 830 citations
  4. 4Actin filaments and the growth, movement, and spread of the intracellular bacterial parasite, Listeria monocytogenes.1989 · 1,281 citations
  5. 5Cellular morphogenesis in the Saccharomyces cerevisiae cell cycle: Localization of the CDC11 gene product and the timing of events at the budding site1991 · 206 citations