Population
Skeletal muscle Ca2+ release channel (RyR1) model
Comparison
Oxidation and alkylation with N-ethylmaleimide vs Unoxidized/unmodified state
Design
Preclinical
Authors
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Oxidation may disrupt RyR1-CaM regulation in skeletal muscle; hypothesis-generating for oxidative effects on calcium release pending in vivo validation.
Oxidation alters the interaction between the skeletal muscle Ca2+ release channel (RyR1) and calmodulin, suggesting a mechanism by which oxidative stress affects channel activity and how calmodulin may offer protective effects.
Zhang et al. (1999) studied this question.
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