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August 20, 2013Diabetes CareOpen Access

Severe hypoglycemia was significantly associated with definite CAN compared to normal autonomic function (HR 2.43, 95% CI 1.21-4.84, p=0.012).

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Why the study?

Does cardiovascular autonomic neuropathy predict severe hypoglycemia in patients with type 2 diabetes?

Population

894 patients with type 2 diabetes, mean age 54.5 years, mean duration of diabetes 8.9 years.

Comparison

Definite cardiovascular autonomic neuropathy vs Normal cardiovascular autonomic function

Design

Cohort

Follow-up

median 9.5 years

Authors

JYJae‐Seung YunJKJi‐Hyun KimKSKi‐Ho Song

Discussion

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Member takes

Overview

Definite CAN may flag higher severe hypoglycemia risk in T2D; hypothesis-generating and requires prospective validation before practice change.

Structured PICO

Does cardiovascular autonomic neuropathy predict severe hypoglycemia in patients with type 2 diabetes?

P
Population
894 patients with type 2 diabetes, mean age 54.5 years, mean duration of diabetes 8.9 years.
I
Intervention
Definite cardiovascular autonomic neuropathy (AFT score ≥2)
C
Comparator
Normal cardiovascular autonomic function (AFT score 0)
O
Outcome
Severe hypoglycemia (SH)hard clinical

Definite cardiovascular autonomic neuropathy is an independent prognostic factor for the development of severe hypoglycemia in patients with type 2 diabetes.

Cite This Study

Yun et al. (2013) studied this question.

synapsesocial.com/papers/6a7206d3a7fbea1e4408913fhttps://doi.org/10.2337/dc13-1164
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Autonomic dysfunction and risk of severe hypoglycemia among individuals with type 2 diabetes2022 · 16 citations
  2. 2Cardiovascular Autonomic Neuropathy Predicts Higher HbA1c Variability in Subjects with Type 2 Diabetes Mellitus2018 · 13 citations
  3. 3Cardiovascular autonomic dysfunction predicts acute ischaemic stroke in patients with Type 2 diabetes mellitus: a 7‐year follow‐up study2008 · 71 citations
  4. 4Cardiovascular autonomic neuropathy is associated with increased glycemic variability driven by hyperglycemia rather than hypoglycemia in patients with diabetes2023 · 15 citations
  5. 5Cardiovascular Autonomic Neuropathy in Patients with Type 2 Diabetes Mellitus2006 · 9 citations